Developmental aspects of parathyroid hormone-related protein biology.

Détails

ID Serval
serval:BIB_C3582BAFC5A1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Developmental aspects of parathyroid hormone-related protein biology.
Périodique
Seminars in Perinatology
Auteur(s)
Escande B., Lindner V., Massfelder T., Helwig J.J., Simeoni U.
ISSN
0146-0005 (Print)
ISSN-L
0146-0005
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
25
Numéro
2
Pages
76-84
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Parathyroid hormone-related protein (PTHrP) has been discovered as a parathyroid hormone (PTH)-like factor responsible for the humoral hypercalcaemia of malignancies. Further studies revealed that PTHrP is ubiquitously expressed, in mature as well as in developing normal tissues from various species. Although not completely understood, the biological roles of PTHrP concern a variety of domains, including calcium phosphorus metabolism and bone mineralization, smooth muscle relaxation, cell growth and differentiation, and embryonic development. As a poly-hormone, PTHrP is now acknowledged to act via the paracrine, autocrine, and even the intracrine pathways. This review focuses on the main developmental features of the biology of PTHrP. During embryonic development, PTHrP is considered to be involved as a growth factor that promotes cell proliferation and delays cell terminal maturation. PTHrP has been shown to intervene in the development of various tissues and organs such as the skeleton, skin, hair follicles, tooth, pancreas, and the kidney. In addition, through its midregion sequence, which is able to promote an active transplacental calcium transport, PTHrP may intervene indirectly in the mineralization of the foetal skeleton. PTHrP has also been shown to be necessary for the normal development of the mammary gland, while huge amounts of PTHrP are found in the human milk. Finally, observations of physiologic, vasodilating effects of PTHrP in the kidney suggest its involvment in the control of renal hemodynamics, especially in the perinatal period.
Mots-clé
Animals, Bone Development, Breast/physiology, Cardiovascular System/embryology, Cardiovascular System/growth & development, Embryonic and Fetal Development, Female, Growth, Humans, Kidney/embryology, Kidney/growth & development, Parathyroid Hormone-Related Protein, Placenta/physiology, Pregnancy, Proteins/chemistry, Proteins/genetics
Pubmed
Web of science
Création de la notice
22/02/2015 10:14
Dernière modification de la notice
03/03/2018 21:11
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