Toward a specific classification of polypoidal choroidal vasculopathy: idiopathic disease or subtype of age-related macular degeneration.

Détails

ID Serval
serval:BIB_C3403643DF2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Toward a specific classification of polypoidal choroidal vasculopathy: idiopathic disease or subtype of age-related macular degeneration.
Périodique
Investigative Ophthalmology and Visual Science
Auteur(s)
Coscas G., Lupidi M., Coscas F., Benjelloun F., Zerbib J., Dirani A., Semoun O., Souied E.H.
ISSN
1552-5783 (Electronic)
ISSN-L
0146-0404
Statut éditorial
Publié
Date de publication
05/2015
Peer-reviewed
Oui
Volume
56
Numéro
5
Pages
3187-3195
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
PURPOSE: To suggest a clinical distinction between idiopathic polypoidal choroidal vasculopathy (PCV) and secondary polyps associated with neovascular age-related macular degeneration (NV-AMD).
METHODS: The study was a retrospective case series of 52 eyes of 52 consecutive patients (31 females and 21 males) diagnosed with PCV. Initial diagnosis was based on scanning laser ophthalmoscope-indocyanine green angiography (SLO-ICGA) in association with fluorescein angiography (FA) and optical coherence tomography (OCT). All the data and images were analyzed in a masked fashion by four experienced examiners in two different sessions: the first, to classify patients into the two hypothesized groups (idiopathic polyps or NV-AMD-related polyps); the second, following a predetermined scheme, to describe objective features. The results obtained in each session underwent a cross multivariate analysis to identify statistically significant differences (P ≤ 0.05) between the two groups.
RESULTS: The two groups were clinically different on the basis of FA (leakage origin [P = 0.001] and presence of drusen [P = 0.001]), ICGA (evidence of choroidal neovascularization [CNV; P = 0.001] and/or branching vascular network [BVN; P = 0.001]), OCT imaging (type of pigmented epithelium detachment [P = 0.001], presence of BVN [P = 0.001], and subfoveal choroidal thickness [P = 0.001]). Further significant differences were observed according to the location of lesion (uni- or multifocal) (P = 0.001), type of CNV (P = 0.001), and best-corrected visual acuity (P = 0.001).
CONCLUSIONS: Our study demonstrated clinical and statistically significant differences between idiopathic PCV and NV-AMD-related polyps that could be considered as distinct entities. Although they share some similarities, mainly the sub-RPE location, the ability to identify a specific clinical pattern suggests a more specific therapeutic approach for these two entities.
Mots-clé
Aged, Aged, 80 and over, Choroid/pathology, Choroidal Neovascularization/classification, Choroidal Neovascularization/diagnosis, Coloring Agents, Diagnosis, Differential, Female, Fluorescein Angiography, Humans, Indocyanine Green, Male, Middle Aged, Multimodal Imaging, Ophthalmoscopy, Polyps/classification, Polyps/diagnosis, Retrospective Studies, Tomography, Optical Coherence, Wet Macular Degeneration/classification, Wet Macular Degeneration/diagnosis
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/02/2016 10:18
Dernière modification de la notice
09/05/2019 0:52
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