Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung function impairment in rabbits

Détails

ID Serval
serval:BIB_C2CD923F115E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung function impairment in rabbits
Périodique
Respiratory Physiology and Neurobiology
Auteur(s)
Habre  W., Scalfaro  P., Schutz  N., Stucki  P., Petak  F.
ISSN
1569-9048 (Print)
Statut éditorial
Publié
Date de publication
05/2006
Volume
152
Numéro
1
Pages
72-82
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
We investigated whether end-expiratory lung volume (EELV) or lung mechanical parameters are more sensitive for the detection of a compromised gas exchange during bronchoconstriction and after surfactant depletion. EELV was determined via SF(6) multiple breath wash-outs in mechanically ventilated rabbits while a positive end-expiratory pressure (PEEP) of 1, 3 or 7 cm H(2)O was maintained. Airway resistance (R(aw)) and parenchymal elastance (H) were estimated from the pulmonary input impedance measured at each PEEP level by means of forced oscillations. Measurements were repeated during i.v. methacholine (MCh) infusions and following lung injury induced by saline lavage. MCh induced marked elevations in R(aw), with no significant change in EELV or H at any PEEP. After lavage, the severity of hypoxia was reflected systematically in significant decreases in EELV at all PEEP levels (-42+/-13%, -26+/-4%, and -18+/-5% at 1, 3 and 7 cm H(2)O, respectively), whereas compromised gas exchange was not associated with consistent changes in the mechanical parameters at a PEEP of 7 cm H(2)O (20+/-9% and 14+/-9% in R(aw) and H, respectively; p=0.2). We conclude that R(aw) is the only sensitive indicator for the detection of a compromised lung function during MCh infusions, whereas the estimation of EELV is necessary to follow the progression of a lung injury when a high PEEP level is applied.
Mots-clé
Airway Resistance/drug effects/physiology Analysis of Variance Animals Bronchoconstrictor Agents/pharmacology Lung Compliance/drug effects/physiology Lung Diseases/diagnosis/*physiopathology Lung Volume Measurements/*methods Male Methacholine Chloride/pharmacology *Positive-Pressure Respiration Pulmonary Gas Exchange/drug effects/physiology Rabbits Respiratory Function Tests/*methods Respiratory Mechanics/drug effects/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 17:46
Dernière modification de la notice
03/03/2018 21:10
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