Family history and the risk of oral and pharyngeal cancer

Détails

ID Serval
serval:BIB_C2C3F629E47F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Family history and the risk of oral and pharyngeal cancer
Périodique
International Journal of Cancer
Auteur(s)
Garavello Werner, Foschi Roberto, Talamini Renato, La Vecchia Carlo, Rossi Marta, Dal Maso Luigino, Tavani Alessandra, Levi Fabio, Barzan Luigi, Ramazzotti Valerio, Franceschi Silvia, Negri Eva
ISSN
0020-7136
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
122
Numéro
8
Pages
1827-1831
Langue
anglais
Résumé
Scanty data are available on familial risk in oral and pharyngeal cancer. The relationship between oral and pharyngeal cancer and family history of cancer in first-degree relatives was investigated using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 2005 on 956 cases aged less than 79 years, with histologically confirmed incident oral and pharyngeal cancer, and 2362 controls admitted to hospital for acute, nonneoplastic conditions. Logistic regression models conditioned on sex, age, study centre, and including terms for education, tobacco smoking, alcohol drinking, and number of siblings were used to estimate the odds ratios (OR) of oral and pharyngeal cancer. The multivariate ORs were similar for a family history of oral and pharyngeal cancer (2.6, 95% confidence interval, CI, 1.5-4.5) and laryngeal cancer (3.8, 95% CI, 2.0-7.2). The OR was 3.1 (95% CI, 2.0-4.8) for oral and pharyngeal cancer and laryngeal cancer combined. The OR was 7.1 (95% CI, 1.3-37.2) for subjects with 2 or more first-degree relatives with oral and pharyngeal/laryngeal cancers. Significant increases in risk were also observed for a family history of melanoma (OR = 5.8; 95% CI, 1.3-26.4) and lung cancer (OR = 1.4; 95% CI, 1.0-2.0). Compared to subjects without family history, nonsmokers, and non or moderate drinkers, the OR was 42.6 for current smokers, heavy drinkers with family history. History of oral and pharyngeal cancer and laryngeal cancer is a strong determinant of oral and pharyngeal cancer risk, independent from tobacco and alcohol.
Mots-clé
Aged, Alcohol Drinking/adverse effects, Case-Control Studies, Confidence Intervals, Family, Female, Humans, Italy/epidemiology, Laryngeal Neoplasms/genetics, Logistic Models, Male, Medical History Taking, Middle Aged, Mouth Neoplasms/epidemiology, Mouth Neoplasms/etiology, Mouth Neoplasms/genetics, Odds Ratio, PharyngealNeoplasms/epidemiology, Pharyngeal Neoplasms/etiology, Pharyngeal Neoplasms/genetics, Risk Assessment, Risk Factors, Smoking/adverse effects, Switzerland/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/04/2008 16:14
Dernière modification de la notice
09/05/2019 0:51
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