Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status

Details

Serval ID
serval:BIB_C249F7D104DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status
Journal
Journal of Neuropathology and Experimental Neurology
Author(s)
Bouras Constantin, Kövari Enikö, Herrmann François R., Rivara Claire Bénédicte, Bailey Thomasina L., Gunten Armin von, Hof Patrick R., Giannakopoulos Panteleimon
ISSN
0022-3069
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
65
Number
3
Pages
235-244
Language
english
Notes
SAPHIRID:61420 --- Old url value: http://www.jneuropath.com/pt/re/jnen/abstract.00005072-200603000-00005.htm
Abstract
The presence of microvascular changes has been documented both in brain aging and Alzheimer disease (AD), although the relationship between the morphometry of brain capillaries and cognitive impairment is still unknown. We performed an analysis of capillary morphometric parameters and AD-related pathology in 19 elderly individuals with variable degrees of cognitive decline. Cognitive status was assessed prospectively using the Clinical Dementia Rating (CDR) scale. Total capillary lengths and numbers as well as mean length-weighted diameter, total neurofibrillary tangle (NFT) and neuron numbers, and amyloid volume were estimated in entorhinal cortex and the CA1 field. Total capillary numbers and mean diameters explained almost 40% of the neuron number variability in both the CA1 and entorhinal cortex. Total capillary length and numbers in the CA1 and entorhinal cortex did not predict cognitive status. Mean capillary diameters in the CA1 and entorhinal cortex were significantly related to CDR scores, explaining 18.5% and 31.1% of the cognitive variability, respectively. This relationship persisted after controlling for NFT and neuron numbers in multivariate regression models. Consistent with the growing interest about microvascular pathology in brain aging, the present data indicate that changes in capillary morphometric parameters may represent independent predictors of AD-related neuronal depletion and cognitive decline
Pubmed
Web of science
Open Access
Yes
Create date
10/03/2008 11:04
Last modification date
20/08/2019 15:37
Usage data