Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra.

Détails

ID Serval
serval:BIB_C1C078C0451C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra.
Périodique
Magnetic Resonance in Medicine
Auteur(s)
Terpstra M., Henry P.G., Gruetter R.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2003
Volume
50
Numéro
1
Pages
19-23
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
The concentration of reduced glutathione (GSH), an antioxidant, may be altered in various brain diseases. MEGA-PRESS was used to edit for the (1)H NMR signal from GSH in the occipital lobe of 12 normal humans. In all studies, GSH was clearly detected with a spectral pattern consistent with spectra acquired from a phantom containing GSH. Retention of singlet resonances in the subspectra, a key advantage of this difference-editing technique, provided an unambiguous reference for the offset and phase of the edited signal. Linear combination model (LCModel) analysis provided an unbiased means for quantifying signal contribution from edited metabolites. GSH concentration was estimated from the in vivo spectra as 1.3 +/- 0.2 micro mol/g (mean +/- SD, n = 12).
Mots-clé
Adult, Algorithms, Aspartic Acid/analogs & derivatives, Aspartic Acid/analysis, Brain Mapping/methods, Female, Glutathione/analysis, Glutathione/chemistry, Humans, Magnetic Resonance Spectroscopy/methods, Male, Occipital Lobe/chemistry, Occipital Lobe/metabolism, Protons, Reproducibility of Results, Sensitivity and Specificity, Subtraction Technique
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
09/05/2019 0:47
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