Rôle du pathologiste dans la prise en charge des tumeurs stromales gastro-intestinales (GIST) [The role of the pathologist in the management of gastrointestinal stromal tumors (GIST)]

Détails

ID Serval
serval:BIB_C0E36FF2F6F7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Rôle du pathologiste dans la prise en charge des tumeurs stromales gastro-intestinales (GIST) [The role of the pathologist in the management of gastrointestinal stromal tumors (GIST)]
Périodique
Revue Médicale Suisse
Auteur(s)
Bouzourene H.
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2009
Volume
5
Numéro
211
Pages
1505-1058
Langue
français
Résumé
Considerable progress was realized these last years in the understanding of the molecular mechanisms and the treatment of the GIST. Their diagnosis remains based on the morphology and immunohistochemistry. The evaluation of GIST prognosis was till know difficult to establish but a new histopronostic classification currently used allows a better therapeutic approach. The search for KIT and PDGFRA mutations is recommended to adapt a targeted therapy by KIT inhibitors. The pathologist plays a crucial role in the management of the GIST because it is on him that is based the diagnosis, the evaluation of the prognosis and the treatment (surgery and kit inhibitors).
Mots-clé
Gastrointestinal Stromal Tumors/genetics, Gastrointestinal Stromal Tumors/pathology, Humans, Protein Kinase Inhibitors/therapeutic use, Proto-Oncogene Proteins c-kit/genetics, Receptor, Platelet-Derived Growth Factor alpha/genetics
Pubmed
Création de la notice
01/10/2009 10:37
Dernière modification de la notice
03/03/2018 21:06
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