FDG-PET as a prognostic factor in high-grade astrocytoma.

Détails

ID Serval
serval:BIB_C0A01119D32E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
FDG-PET as a prognostic factor in high-grade astrocytoma.
Périodique
Journal of Neuro-Oncology
Auteur(s)
De Witte O., Lefranc F., Levivier M., Salmon I., Brotchi J., Goldman S.
ISSN
0167-594X (Print)
ISSN-L
0167-594X
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
49
Numéro
2
Pages
157-163
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND: The prognostic value of the metabolic status of cerebral gliomas determined by positron emission tomography with [18F]-fluoro-deoxy-D-glucose (FDG-PET) has been established in populations with a mixture of grades 2, 3 and 4 gliomas, but remains uncertain when only malignant gliomas are considered (grade 3 and 4).
METHODS: FDG-PET performed in 30 patients with anaplastic astrocytoma (grade III) and 61 patients with glioblastoma (grade 4) were classified according to a metabolic grading. The uptake of FDG was lower in the tumor compared to white matter (WM) in grade 1 (4 glioblastoma, 4 anaplastic astrocytoma), it was intermediate between WM and cortex in grade 2 (20 glioblastoma, 22 anaplastic astrocytoma), and it was superior to cortex in grade 3 (38 glioblastoma, 4 anaplastic astrocytoma).
RESULTS: Kaplan-Meier survival curves were similar in patient with grades 1 and 2, but were significantly worse (p = 0.007) in grade 3. In multivariate analysis considering age, pathological grade (anaplastic astrocytoma versus glioblastoma), and metabolic grades, the metabolic grade did not appear to be an independent prognostic factor. When anaplastic astrocytomas and glioblastomas were considered separately, metabolic grade is of predictive value only in the group of glioblastomas.
CONCLUSION: In malignant gliomas, metabolic grading determined by FDG-PET was not superior to the pathological grading for survival prediction. Still, it remains of predictive value when applied to malignant gliomas histologically classified as glioblastoma.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms/mortality, Brain Neoplasms/radiography, Fluorodeoxyglucose F18/diagnostic use, Glioblastoma/mortality, Glioblastoma/radiography, Humans, Middle Aged, Neoplasm Staging, Prognosis, Radiopharmaceuticals/diagnostic use, Survival Rate, Tomography, Emission-Computed/methods
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
03/03/2018 21:06
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