Prognostic parameters of metastatic adrenocortical carcinoma

Details

Serval ID
serval:BIB_C07A0EE0A373
Type
Article: article from journal or magazin.
Collection
Publications
Title
Prognostic parameters of metastatic adrenocortical carcinoma
Journal
J Clin Endocrinol Metab
Author(s)
Assie G., Antoni G., Tissier F., Caillou B., Abiven G., Gicquel C., Leboulleux S., Travagli J. P., Dromain C., Bertagna X., Bertherat J., Schlumberger M., Baudin E.
ISSN-L
0021-972X (Print)0021-972X (Linking)
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
92
Number
1
Pages
148-54
Language
english
Notes
Assie, GuillaumeAntoni, GuillemetteTissier, FrederiqueCaillou, BernardAbiven, GwenaelleGicquel, ChristineLeboulleux, SophieTravagli, Jean-PaulDromain, ClarisseBertagna, XavierBertherat, JeromeSchlumberger, MartinBaudin, EricengResearch Support, Non-U.S. Gov't2006/10/26 09:00J Clin Endocrinol Metab. 2007 Jan;92(1):148-54. Epub 2006 Oct 24.
Abstract
CONTEXT: Prognostic parameters of metastatic adrenocortical carcinoma (ACC) are poorly characterized. OBJECTIVE: The objective of the study was to describe the clinical presentation of metastatic ACC and determine prognostic factors for survival. DESIGN: This was a retrospective cohort study (1988-2004). SETTING: The study was conducted in an institutional practice. PATIENTS: Participants included 124 consecutive patients with metastatic ACC, 70 from Gustave-Roussy Institute (main cohort) and 54 patients from the Cochin Hospital (validation cohort). Clinical data concerning all patients, histopathologic slides of primary tumors (44 in the main cohort and 40 in the validation cohort), and molecular biology data on 15 primary tumors (main cohort) were analyzed. INTERVENTION: There was no intervention. MAIN OUTCOME: The main outcome was the specific survival after discovery of the first metastasis (Kaplan-Meier method). This included univariate analysis on the main cohort, confirmed on the validation cohort and then analyzed in a multivariate analysis. RESULTS: In the main cohort, overall median survival was 20 months. In univariate analysis, the presence of hepatic and bone metastases, the number of metastatic lesions and the number of tumoral organs at the time of the first metastasis, a high mitotic rate (>20 per 50 high-power field), and atypical mitoses in the primary tumor predicted survival (P = 0.05, 0.003, 0.046, 0.001, 0.01, and < 0.001, respectively). The number of tumoral organs and a high mitotic rate were confirmed on the validation cohort (P = 0.009 and 0.03, respectively). These two parameters were confirmed in multivariate analysis (P = 0.0058 and 0.049). CONCLUSION: Metastatic ACC is a heterogeneous disease with poor outcome. The combination of the number of tumoral organs at the time of the first metastasis and the mitotic rate can predict different outcomes.
Keywords
Adolescent, Adrenal Cortex Neoplasms/genetics/*mortality/pathology, Adult, Aged, Bone Neoplasms/secondary, Cohort Studies, Female, Humans, Liver Neoplasms/secondary, Loss of Heterozygosity, Male, Middle Aged, Multivariate Analysis, Prognosis, Retrospective Studies, Survival Rate
Open Access
Yes
Create date
16/09/2016 10:13
Last modification date
20/08/2019 15:34
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