Effects of endotoxin on isolated porcine liver: pressure-flow analysis

Details

Serval ID
serval:BIB_BF35176C84DD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of endotoxin on isolated porcine liver: pressure-flow analysis
Journal
Journal of Applied Physiology
Author(s)
Brienza  N., Ayuse  T., Revelly  J. P., O'Donnell  C. P., Robotham  J. L.
ISSN
8750-7587 (Print)
Publication state
Published
Issued date
03/1995
Volume
78
Number
3
Pages
784-92
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Abstract
The peripheral vascular response to sepsis is characterized by a vasodilatation of the systemic arterial vessels. Pulmonary hypertension with an increase in resistance and back pressure to flow defined by pressure-flow (P-Q) relationships has been reported in experimental sepsis. We hypothesized that endotoxin can induce differential alterations in resistance and back pressure to flow in the liver venous and arterial beds. Ninety minutes after endotoxin administration in intact anesthetized pigs (n = 8), the liver was vascularly isolated and perfused. Steady-state P-Q relationships in both the portal vein (PV) and hepatic artery (HA) were generated at multiple outflow pressures (Pout; 0, 5, 10, and 15 mmHg) and compared with those obtained in control livers (n = 6). Extrapolated zero-flow pressure intercepts (Pback) and slopes of the P-Q relationships were obtained by least squares linear regression analysis. Endotoxemia increased PV Pback (P < 0.05), and Pback always exceeded Pout (P < 0.05) when the latter was raised. In contrast, in controls, no difference was observed between Pback and Pout when the latter was raised. Endotoxemia also increased the PV slope compared with control. Raising Pout from 0 to 15 mmHg decreased PV slope in the endotoxin group to a greater degree than in controls (P < 0.05). In the HA, endotoxin caused a decrease in slope but did not alter Pback. The simultaneous increase in the PV Pback and slope that occurs with endotoxemia decreases splanchnic venous return, pooling blood in the splanchnic compartment for a given total blood volume.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Animals Blood Pressure/*drug effects Endotoxins/*pharmacology Escherichia coli Female Hepatic Artery/drug effects/physiology Liver/*drug effects Liver Circulation/*drug effects Portal Vein/drug effects/physiology Swine
Pubmed
Web of science
Create date
24/01/2008 17:03
Last modification date
20/08/2019 15:33
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