Effect of glucose on ureagenesis during exercise in amino acid-infused dogs

Details

Serval ID
serval:BIB_BED6DB633706
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of glucose on ureagenesis during exercise in amino acid-infused dogs
Journal
Metabolism: Clinical and Experimental
Author(s)
Hamada K., Matsumoto K., Minehira K., Doi T., Okamura K., Shimizu S.
ISSN
0026-0495
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
47
Number
11
Pages
1303-1037
Language
english
Abstract
The purpose of this study was to investigate the effect of glucose administered with amino acids before and during exercise on hepatic ureagenesis. Eight mongrel dogs subjected to treadmill running for 150 minutes at 10 km/h on a 12% incline were intravenously infused with either a mixture of amino acids and glucose (AAG) or amino acids alone (AA). The infusion was started 60 minutes before exercise and continued until the end of exercise. The rate of urinary urea excretion increased after infusion of both AAG and AA. However, the rate of urinary urea excretion was significantly lower in the AAG group versus the AA group during the first 1.5 hours of the recovery period ([R0 to R90] 514+/-24 v 637+/-24 mg/h, mean+/-SE, P < .05). Moreover, hepatic urea output was decreased during AAG versus AA infusion (229+/-62 v 367+/-55 microg/kg/min, P < .05). Hepatic glucose production during exercise was also significantly lower in AAG versus AA infusion (354+/-54 v 589+/-56 mg/kg, P < .05). On the other hand, no difference was observed in hepatic total amino acid uptake between the groups. Thus, these results indicate that AAG administered before and during exercise appears to reduce hepatic ureagenesis due to reduced hepatic gluconeogenesis as compared with administration of AA alone. These findings also suggest that nitrogen retention is enhanced by glucose administered during exercise.
Keywords
Amino Acids/*administration & dosage/metabolismAnimalsDogsGlucose/administration & dosage/biosynthesis/*pharmacologyInsulin/bloodLiver/blood supply/drug effects/metabolismMale*Physical Conditioning, AnimalRegional Blood Flow/drug effectsUrea/blood/*metabolism/urine
Pubmed
Web of science
Create date
20/02/2009 12:43
Last modification date
20/08/2019 15:33
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