Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts.

Details

Serval ID
serval:BIB_BDFAD47D5459
Type
Article: article from journal or magazin.
Collection
Publications
Title
Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts.
Journal
Annals of Neurology
Author(s)
Wise R.J., Rhodes C.G., Gibbs J.M., Hatazawa J., Palmer T., Frackowiak R.S., Jones T.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
1983
Volume
14
Number
6
Pages
627-637
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Eight patients with recent cerebral hemispheric infarction were studied with positron emission tomography and the oxygen-15 steady-state inhalation and [18F]deoxyglucose techniques to obtain values of regional cerebral blood flow, oxygen consumption, and glucose metabolism. The Sokoloff equation, used to calculate glucose metabolism, was simplified to exclude the exponential terms containing the rate constants. A value of the lumped constant quoted for normal brain (0.42) was used for infarcted regions and contralateral hemisphere. Mean regional cerebral blood flow, oxygen consumption, and glucose metabolism were all significantly depressed within the infarcts compared with the mirror regions in the contralateral cerebral hemisphere. The mean fractional extraction of oxygen was low, indicating an adequate supply of oxygen for residual oxidative metabolism. Regional oxygen consumption and glucose metabolism were significantly correlated within the infarcts, but with a relationship of 2 moles of oxygen per mole of glucose--one-third that in the contralateral hemisphere and in normal brain. Although these results suggest that the metabolizing tissue of a recent cerebral infarct utilizes aerobic glycolysis, caution about the validity of this pathophysiological observation is dictated by limitations in current positron emission tomographic tracer methodology.
Keywords
Adult, Aged, Brain/metabolism, Cerebral Infarction/metabolism, Cerebral Infarction/physiopathology, Cerebrovascular Circulation, Deoxyglucose/analogs & derivatives, Deoxyglucose/diagnostic use, Energy Metabolism, Female, Fluorodeoxyglucose F18, Glucose/metabolism, Humans, Male, Middle Aged, Oxygen/metabolism, Oxygen Consumption, Oxygen Radioisotopes/diagnostic use, Tomography, Emission-Computed
Pubmed
Web of science
Create date
09/10/2011 17:44
Last modification date
20/08/2019 15:32
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