Immunohistochemical localization of acidic fibroblast growth factor in normal human enterochromaffin cells and related gastrointestinal tumours.

Détails

ID Serval
serval:BIB_BDC6CAFA350E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Immunohistochemical localization of acidic fibroblast growth factor in normal human enterochromaffin cells and related gastrointestinal tumours.
Périodique
Virchows Archiv : An International Journal of Pathology
Auteur(s)
La Rosa S., Chiaravalli A.M., Capella C., Uccella S., Sessa F.
ISSN
0945-6317 (Print)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
430
Numéro
2
Pages
117-124
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Acidic fibroblast growth factor (aFGF) is a member of the structurally related heparin-binding growth factor family. The best studied members of this family are aFGF and basic FGF (bFGF), which are potent mitogens and differentiation factors for mesoderm-derived cells, including fibroblasts. This study was designed to verify the immunohistochemical expression of aFGF in normal human endocrine cells of the gut and in related endocrine tumours. We examined normal gastrointestinal mucosa from seven different subjects and 41 gut endocrine tumours from different sites, including stomach, duodenum, and small and large intestine, using an aFGF polyclonal antibody with no cross-reactivity for bFGF. We localized aFGF in a fraction of serotonin-producing enterochromaffin (EC) cells of the normal gut, while it was absent in gastrin (G), CCK, secretion (S), somatostatin (D) and glicentin (L) cells. aFGF immunoreactivity was also expressed in serotonin producing EC cell tumours, but not in other functional types of gut endocrine neoplasms investigated, including gastric ECL cell, duodenal somatostatin and gastrin cell, and rectal L cell tumours. A positive correlation was found between expression of aFGF and the amount of tumour fibrous stroma, suggesting that aFGF may be involved in proliferation and activity of stromal fibroblasts.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies/analysis, Carcinoid Tumor/metabolism, Carcinoid Tumor/pathology, Duodenum/chemistry, Duodenum/cytology, Enterochromaffin Cells/cytology, Enterochromaffin Cells/metabolism, Female, Fibroblast Growth Factor 1/analysis, Fibroblast Growth Factor 1/biosynthesis, Gastrointestinal Neoplasms/metabolism, Gastrointestinal Neoplasms/pathology, Humans, Ileum/chemistry, Ileum/cytology, Immunohistochemistry, Male, Middle Aged, Reference Values, Serotonin/analysis, Somatostatin/analysis
Pubmed
Web of science
Création de la notice
07/09/2016 9:42
Dernière modification de la notice
03/03/2018 20:59
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