Capillarization of the sinusoids in liver fibrosis: noninvasive assessment with contrast-enhanced MRI in the rabbit.

Détails

ID Serval
serval:BIB_BDB94498913D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Capillarization of the sinusoids in liver fibrosis: noninvasive assessment with contrast-enhanced MRI in the rabbit.
Périodique
Magnetic Resonance In Medicine
Auteur(s)
Van Beers B.E., Materne R., Annet L., Hermoye L., Sempoux C., Peeters F., Smith A.M., Jamart J., Horsmans Y.
ISSN
0740-3194 (Print)
ISSN-L
0740-3194
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
49
Numéro
4
Pages
692-699
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Sinusoidal capillarization induces microcirculatory changes in liver cirrhosis and fibrosis. The purpose of this study was to assess whether contrast-enhanced MRI can be used to demonstrate the effects of sinusoidal capillarization in liver fibrosis. Dynamic MRI after injection of a low-molecular-weight contrast agent of 0.56 kDa (Gd-DOTA), and two high-molecular-weight contrast agents of 6.47 kDa and 52 kDa (P792 and P717) was performed in rabbits with liver fibrosis induced by cholesterol and diethylstilbestrol. The hepatic distribution volume accessible to the high-molecular-weight agents decreased in the rabbits with liver fibrosis (P792: 7.8% +/- 1.7% vs. 10.1% +/- 1.8% in normal rabbits, P =.038; P717: 6.2% +/- 2.1% vs. 9.7% +/- 1.6% in normal rabbits, P =.007), whereas the hepatic mean transit time (MTT) of the low-molecular-weight agent was increased (15.9 +/- 8.0 s vs. 8.8 +/- 2.6 s in normal rabbits, P =.015). In rabbits with liver fibrosis, the clearance of indocyanine green (ICG) was correlated with the volume accessible to the high-molecular-weight agents (P792: r = 0.810, P =.015; P717: r = 0.857, P =.007). The collagen content of the liver was inversely correlated with the distribution volume of P717 (r = -.833, P =.010) and with the ICG clearance (r = -.810, P =.015). It was concluded that the microcirculatory changes induced by sinusoidal capillarization in liver fibrosis can be demonstrated noninvasively with MRI.
Mots-clé
Animals, Capillary Permeability, Cholesterol, Contrast Media, Heterocyclic Compounds, Image Processing, Computer-Assisted, Liver/blood supply, Liver Cirrhosis, Experimental/chemically induced, Liver Cirrhosis, Experimental/diagnosis, Magnetic Resonance Imaging, Male, Microcirculation, Organometallic Compounds, Rabbits
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/10/2016 17:28
Dernière modification de la notice
09/05/2019 0:34
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