Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence.

Détails

ID Serval
serval:BIB_BD9C72C19FE4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence.
Périodique
European Geriatric Medicine
Auteur(s)
Lang PO, Mitchell W, Lapenna A, Pitts D, Aspinall R.
ISSN
1878-7649
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
1
Numéro
2
Pages
112-21
Langue
anglais
Résumé
Nowadays, it is well known that with advancing age individuals are at an increased susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer, and osteoporosis. Ageing is associated with various changes in immune parameters: therefore many authors have postulated that these age-related diseases could be explained, at least in part, by an overall deregulation of the function of the immune system. Immunosenescence is the term usually used to describe the acquired dysfunctional immunity within the ageing population affecting both innate and adaptive immunity. The present review examines the close involvement of the immunosenescence in the pathogenesis of these main age-related clinical outcomes, insulin resistance and the frailty process.
Web of science
Création de la notice
15/04/2015 10:36
Dernière modification de la notice
03/03/2018 20:59
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