Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.

Details

Serval ID
serval:BIB_BD6D5F321010
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.
Journal
Journal of interferon & cytokine research
Author(s)
Pot C., Apetoh L., Awasthi A., Kuchroo V.K.
ISSN
1557-7465 (Electronic)
ISSN-L
1079-9907
Publication state
Published
Issued date
06/2010
Peer-reviewed
Oui
Volume
30
Number
6
Pages
381-388
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Type 1 regulatory (Tr1) cells have emerged as key players in the prevention of autoimmunity. They produce high levels of the immunosuppressive cytokine interleukin (IL)-10 and confer protection against a wide panel of autoimmune diseases. However, the molecular pathways leading to their generation have long remained elusive. We have recently identified IL-27, a member of the IL-12 cytokine family, as a novel cytokine that induces Tr1 cells. Further analysis of IL-27-driven Tr1 cells have identified a critical role of the transcription factor avian musculoaponeurotic fibrosarcoma v-maf and of IL-21 in the generation of IL-27-induced Tr1 cells. Importantly, IL-27 also induces Tr1 cells in humans, suggesting that IL-27 administration may dampen tissue inflammation in humans as well. Here, we review the role of IL-27 in the generation of Tr1 cells and discuss its potential to alleviate autoimmune diseases.
Keywords
Animals, Autoimmune Diseases/immunology, Autoimmune Diseases/prevention & control, Humans, Interleukin-10/immunology, Interleukin-10/secretion, Interleukins/immunology, Oncogene Protein v-maf/immunology, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism
Pubmed
Web of science
Create date
21/08/2018 16:11
Last modification date
20/08/2019 15:31
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