Pulmonary hypertension.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_BD4F7CAC07A0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pulmonary hypertension.
Périodique
Swiss medical weekly
Auteur(s)
Nicod L.P.
ISSN
1424-7860 (Print)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
22/02/2003
Peer-reviewed
Oui
Volume
133
Numéro
7-8
Pages
103-110
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Pulmonary arterial hypertension (PAH) must be classified into primary pulmonary hypertension and PAH related to other diseases such as collagen vascular diseases, HIV infection or portal hypertension. PAH must also be differentiated from other entities, in particular pulmonary hypertension secondary to thromboembolic diseases, requiring specific approaches. All PAH results in similar histological remodelling of pulmonary arteries, with thickening of the intima, proliferation of the media and plexogenic lesions. Today the physiopathology of these lesions is much better understood and has resulted in new therapies involving substances such as prostacyclins, endothelin receptor antagonists or phosphodiesterase inhibitors, aimed not only at dilating arteries but also at preventing their remodelling. Thromboendarterectomy, septostomy and transplantation remain the only option where medical treatment has failed.

Mots-clé
Humans, Hypertension, Pulmonary/physiopathology
Pubmed
Web of science
Création de la notice
23/02/2010 16:28
Dernière modification de la notice
11/06/2018 12:48
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