Cortical mechanisms underlying stretch reflex adaptation to intention: A combined EEG-TMS study

Details

Serval ID
serval:BIB_BD1705B79B1A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cortical mechanisms underlying stretch reflex adaptation to intention: A combined EEG-TMS study
Journal
NeuroImage
Author(s)
Spieser Laure, Meziane Hadj Boumediene, Bonnard Mireille
ISSN
1053-8119
Publication state
Published
Issued date
2010
Volume
52
Number
1
Pages
316--325
Language
english
Notes
Spieser2010
Abstract
During voluntary motor acts, potential perturbations due to transient external forces are counteracted very quickly by short- and long-latency stretch reflexes (SLSR and LLSR, respectively). The LLSR, presumably linked to a transcortical loop, can be modulated by the subjects' intention. Here, we used combined TMS-EEG to study cortical mechanisms involved in this intention-related modulation both before and during the reaction to a mechanical perturbation. Subjects had to prepare for a brisk wrist extension under the instruction either to 'resist' the perturbation or to 'let-go'. Following the perturbation, the early cortical evoked activity (45-75. ms) was greater in the 'let-go' condition; moreover, its amplitude was negatively correlated with the LLSR amplitude, regardless of condition. After 100. ms the pattern reversed, the late evoked activity (presumably linked to the voluntary reaction) was greater in the 'resist' condition. The early and late evoked activities also differed in their topography. Therefore, the cortical mechanisms involved in the intention-related LLSR modulation differ from those involved in the voluntary reaction. In addition, in response to a single-pulse TMS delivered during the expectation of the mechanical perturbation, the TMS-evoked N100 amplitude decreased when subjects intended to 'let-go', suggesting anticipatory decreased activity of intracortical inhibitory sensorimotor networks. Taken together, these results support the idea that anticipatory processes preset the sensorimotor cortex so as to adapt its early reaction to the perturbation relative to the subjects' intention. ?? 2010 Elsevier Inc.
Keywords
Cortical evoked potentials,Mechanical perturbation,Motor cortex,Motor preparation,Stretch reflex modulation
Pubmed
Create date
31/03/2016 14:59
Last modification date
21/01/2020 15:03
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