Effect of Three Hypopnea Scoring Criteria on OSA Prevalence and Associated Comorbidities in the General Population.

Détails

ID Serval
serval:BIB_BCEE62B205A1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of Three Hypopnea Scoring Criteria on OSA Prevalence and Associated Comorbidities in the General Population.
Périodique
Journal of clinical sleep medicine
Auteur(s)
Hirotsu C., Haba-Rubio J., Andries D., Tobback N., Marques-Vidal P., Vollenweider P., Waeber G., Heinzer R.
ISSN
1550-9397 (Electronic)
ISSN-L
1550-9389
Statut éditorial
Publié
Date de publication
15/02/2019
Peer-reviewed
Oui
Volume
15
Numéro
2
Pages
183-194
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Apnea-hypopnea index (AHI) is the main polysomnographic measure to diagnose obstructive sleep apnea (OSA). We aimed to evaluate the effect of three standard hypopnea definitions on the prevalence of OSA and its association with cardiometabolic outcomes in the general population.
We analyzed data from the HypnoLaus study (Lausanne, Switzerland), in which 2,162 participants (51% women, 57 ± 19 years) underwent in-home full polysomnography. AHI was calculated using three hypopnea definitions: AASM <sub>1999</sub> (≥ 50% decrease in airflow or lower airflow reduction associated with oxygen desaturation ≥ 3% or an arousal), AASM <sub>2007</sub> (≥ 30% airflow reduction associated with ≥ 4% oxygen desaturation), and AASM <sub>2012</sub> <sub>(≥</sub> 30% airflow reduction associated with ≥ 3% oxygen desaturation or an arousal). Participants underwent clinical assessment for hypertension, diabetes, and metabolic syndrome.
Median AHI of AASM <sub>1999</sub> , AASM <sub>2007</sub> and AASM <sub>2012</sub> criteria were 10.9, 4.4, and 10.1 events/h, respectively. OSA prevalence defined as AHI ≥ 5, ≥ 15, and ≥ 30 events/h was 74.5%, 39.3%, and 16.3% using AASM <sub>1999</sub> ; 46.9%, 18.8%, and 6.8% using AASM <sub>2007</sub> ; and 72.2%, 36.6%, and 14.9% using AASM <sub>2012</sub> . Different AHI thresholds derived from AASM <sub>1999</sub> , AASM <sub>2007</sub> , and AASM <sub>2012</sub> criteria <sub>,</sub> respectively, were associated with hypertension (11.5, 4.8, 10.7 events/h), diabetes (15.7, 7.1, 14.4 events/h), and metabolic syndrome (12.8, 5.5, 11.8 events/h).
Hypopnea definition has a major effect on AHI and on OSA prevalence in the general population and, hence, important implications for public health policies. There is a twofold difference in the threshold above which an association with diabetes, hypertension, and metabolic syndrome is observed using AASM <sub>2007</sub> compared to AASM <sub>1999</sub> or AASM <sub>2012</sub> criteria.
Mots-clé
general population, hypopnea, methodology, obstructive sleep apnea, polysomnography
Pubmed
Web of science
Création de la notice
13/03/2019 15:45
Dernière modification de la notice
20/08/2019 16:31
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