Article: article from journal or magazin.
Variations in the in vivo P-31 MR spectra of the developing human brain during postnatal life. Work in progress
0033-8419 0033-8419 (Linking)
Research Support, Non-U.S. Gov't Boesch, C Gruetter, R Martin, E Duc, G Wuthrich, K United states Radiology Radiology. 1989 Jul;172(1):197-9.
With use of a modified surface coil technique, the authors recorded phosphorus-31 magnetic resonance (MR) spectra of the brains of 40 neonates and infants (48 examinations) ranging from 33 weeks postconceptional age to 6 years of age. Signals of phosphorus metabolites were collected in the frontotemporal region of the brain, and various P-31 MR spectral variables were compared at different times during postnatal life. The ratio of the phosphomonoester signal to the phosphodiester signal, which is related to phospholipid synthesis, decreases within the first 6 months of life; during the same time period, the ratio of the phosphocreatine (PCr) signal to the beta-adenosine triphosphate (ATP) signal increases. In addition, a difference was observed between the areas under the alpha- and beta-ATP peaks. This difference increases with age and correlates with the PCr/beta-ATP signal ratio. The variation of the alpha-ATP peak with age might be explained by overlap of the signals of nicotinamide adenine dinucleotide (NAD) and alpha-ATP.
Adenosine Triphosphate/metabolism Brain/*growth & development/metabolism Child Child, Preschool Humans Infant Infant, Newborn Magnetic Resonance Spectroscopy/*diagnostic use Phosphocreatine/metabolism
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