Functional role of type I and type II interferons in antiviral defense.

Details

Serval ID
serval:BIB_BC616EF660B2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Functional role of type I and type II interferons in antiviral defense.
Journal
Science
Author(s)
Müller U., Steinhoff U., Reis L.F., Hemmi S., Pavlovic J., Zinkernagel R.M., Aguet M.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Publication state
Published
Issued date
1994
Volume
264
Number
5167
Pages
1918-1921
Language
english
Abstract
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Keywords
Alphavirus Infections/immunology, Animals, Antibodies, Viral/biosynthesis, Disease Susceptibility, Immunity, Innate, Interferon Type I/physiology, Interferon-gamma/physiology, Lymphocytic Choriomeningitis/immunology, Membrane Proteins, Mice, Mutation, Receptor, Interferon alpha-beta, Receptors, Interferon/genetics, Receptors, Interferon/physiology, Rhabdoviridae Infections/immunology, Semliki forest virus, Signal Transduction, T-Lymphocytes/immunology, Vesicular stomatitis Indiana virus, Virus Diseases/immunology
Pubmed
Web of science
Create date
28/01/2008 11:37
Last modification date
20/08/2019 15:30
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