Article: article from journal or magazin.
Functional role of type I and type II interferons in antiviral defense.
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Alphavirus Infections/immunology, Animals, Antibodies, Viral/biosynthesis, Disease Susceptibility, Immunity, Innate, Interferon Type I/physiology, Interferon-gamma/physiology, Lymphocytic Choriomeningitis/immunology, Membrane Proteins, Mice, Mutation, Receptor, Interferon alpha-beta, Receptors, Interferon/genetics, Receptors, Interferon/physiology, Rhabdoviridae Infections/immunology, Semliki forest virus, Signal Transduction, T-Lymphocytes/immunology, Vesicular stomatitis Indiana virus, Virus Diseases/immunology
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