Isolated necrotizing arteritis of the female genital tract: a clinicopathologic and immunohistochemical study of 11 cases

Details

Serval ID
serval:BIB_BBD2A53FD931
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Isolated necrotizing arteritis of the female genital tract: a clinicopathologic and immunohistochemical study of 11 cases
Journal
International Journal of Gynecological Pathology
Author(s)
Francke  M. L., Mihaescu  A., Chaubert  P.
ISSN
0277-1691 (Print)
Publication state
Published
Issued date
1998
Volume
17
Number
3
Pages
193-200
Notes
PT - Journal Article
Abstract
Isolated necrotizing arteritis (INA) of the polyarteritis-nodosa type localized to the female genital tract is rare. Approximately 30 case reports have been published to date. Eleven additional patients are described here, all with a favorable follow-up. INA is usually localized in the uterine cervix, but, when multifocal lesions are present, the latter is almost always involved. Patients most frequently report menorrhagia or postmenopausal bleeding. With immunohistochemical studies, immune-complex deposits (IgM, IgG, and C'3) in 7 of 11 patients with INA of the female genital tract were demonstrated for the first time. The inflammatory cells were composed mainly of T-lymphocytes with macrophages and scarce B-lymphocytes also present. These results suggest that INA is primarily an immune complex-mediated disease, implicating humoral and cellular mediator systems. Possible pathogenetic factors of INA are immune complex-mediated hypersensitivity reactions to drugs, foreign materials (after cone biopsy or curettage), and cancers, or an autoimmune reaction against constituents of the vessel walls caused by tissue injury after local surgical intervention through in situ immune-complex formation
Keywords
Adult/Aged/B-Lymphocytes/cytology/Female/Fibrinogen/metabolism/Genital Diseases,Female/immunology/Pathology/Humans/Immunoenzyme Techniques/Immunoglobulins/analysis/Immunophenotyping/Macrophages/Middle Aged/Polyarteritis Nodosa/T-Lymphocytes
Pubmed
Web of science
Create date
29/01/2008 19:36
Last modification date
20/08/2019 16:29
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