Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
GC-MS procedure for the analysis of zipeprol.
Journal of Pharmaceutical and Biomedical Analysis
A sensitive and specific quantitative method for the determination of zipeprol, a newly abused antitussive, in human fluids is described. Zipeprol and an internal standard, levallorphan, are isolated by a basic extraction and back-extraction process. The final extract is derivatizated with BSTFA + 1% TMCS and separated on a 12-m HP-1 capillary column. Drugs are detected by selected ion monitoring at m/z 335 and m/z 355 for zipeprol and the internal standard, respectively. The minimum detectable quantities are 0.6 and 0.4 ng ml-1, for zipeprol in plasma and urine, respectively. Relative standard deviations for within-run data are less than 6%.
Adult, Antitussive Agents/analysis, Antitussive Agents/blood, Gas Chromatography-Mass Spectrometry, Gastrointestinal Contents/chemistry, Humans, Indicators and Reagents, Levallorphan/analysis, Male, Piperazines/analysis, Piperazines/blood, Solvents, Suicide, Attempted
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