Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases
PT - Case Reports PT - Journal Article
Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiation-associated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiation-associated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas
Adult/Female/Humans/Immunohistochemistry/Lung Neoplasms/secondary/Neoplasm Proteins/genetics/Neoplasms,Radiation-Induced/metabolism/Pathology/Neoplasms,Second Primary/Repressor Proteins/Reverse Transcriptase Polymerase Chain Reaction/Sarcoma,Synovial/Soft Tissue Neoplasms/Translocation,Genetic
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