Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

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Serval ID
serval:BIB_B7C63B429520
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Journal
Nature Genetics
Author(s)
Schunkert H., König I.R., Kathiresan S., Reilly M.P., Assimes T.L., Holm H., Preuss M., Stewart A.F., Barbalic M., Gieger C., Absher D., Aherrahrou Z., Allayee H., Altshuler D., Anand S.S., Andersen K., Anderson J.L., Ardissino D., Ball S.G., Balmforth A.J., Barnes T.A., Becker D.M., Becker L.C., Berger K., Bis J.C., Boekholdt S.M., Boerwinkle E., Braund P.S., Brown M.J., Burnett M.S., Buysschaert I., Cardiogenics , Carlquist J.F., Carlquist J.F., Chen L., Cichon S., Codd V., Davies R.W., Dedoussis G., Dehghan A., Demissie S., Devaney J.M., Diemert P., Do R., Doering A., Eifert S., Mokhtari N.E., Ellis S.G., Elosua R., Engert J.C., Epstein S.E., de Faire U., Fischer M., Folsom A.R., Freyer J., Gigante B., Girelli D., Gretarsdottir S., Gudnason V., Gulcher J.R., Halperin E., Hammond N., Hazen S.L., Hofman A., Horne B.D., Illig T., Iribarren C., Jones G.T., Jukema J.W., Kaiser M.A., Kaplan L.M., Kastelein J.J., Khaw K.T., Knowles J.W., Kolovou G., Kong A., Laaksonen R., Lambrechts D., Leander K., Lettre G., Li M., Lieb W., Loley C., Lotery A.J., Mannucci P.M., Maouche S., Martinelli N., McKeown P.P., Meisinger C., Meitinger T., Melander O., Merlini P.A., Mooser V., Morgan T., Mühleisen T.W., Muhlestein J.B., Münzel T., Musunuru K., Nahrstaedt J., Nelson C.P., Nöthen M.M., Olivieri O., Patel R.S., Patterson C.C., Peters A., Peyvandi F., Qu L., Quyyumi A.A., Rader D.J., Rallidis L.S., Rice C., Rosendaal F.R., Rubin D., Salomaa V., Sampietro M.L., Sandhu M.S., Schadt E., Schäfer A., Schillert A., Schreiber S., Schrezenmeir J., Schwartz S.M., Siscovick D.S., Sivananthan M., Sivapalaratnam S., Smith A., Smith T.B., Snoep J.D., Soranzo N., Spertus J.A., Stark K., Stirrups K., Stoll M., Tang W.H., Tennstedt S., Thorgeirsson G., Thorleifsson G., Tomaszewski M., Uitterlinden A.G., van Rij A.M., Voight B.F., Wareham N.J., Wells G.A., Wichmann H.E., Wild P.S., Willenborg C., Witteman J.C., Wright B.J., Ye S., Zeller T., Ziegler A., Cambien F., Goodall A.H., Cupples L.A., Quertermous T., März W., Hengstenberg C., Blankenberg S., Ouwehand W.H., Hall A.S., Deloukas P., Thompson J.R., Stefansson K., Roberts R., Thorsteinsdottir U., O'Donnell C.J., McPherson R., Erdmann J., Samani N.J., Samani N.J.
Working group(s)
CARDIoGRAM Consortium
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
2011
Volume
43
Number
4
Pages
333-338
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
Keywords
Adult, Aged, Alleles, Case-Control Studies, Coronary Artery Disease/etiology, Coronary Artery Disease/genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors
DOI
10.1038/ng.784
Pubmed
21378990
Web of science
000288903700013
Create date
22/03/2012 10:44
Last modification date
20/08/2019 16:25
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