Barriers in the immature brain

Details

Serval ID
serval:BIB_B7B81B50AC03
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Barriers in the immature brain
Journal
Cellular and Molecular Neurobiology
Author(s)
Saunders  N. R., Knott  G. W., Dziegielewska  K. M.
ISSN
0272-4340 (Print)
Publication state
Published
Issued date
02/2000
Volume
20
Number
1
Pages
29-40
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Abstract
1. The term "blood-brain barrier" describes a range of mechanisms that control the exchange of molecules between the internal environment of the brain and the rest of the body. 2. The underlying morphological feature of these barriers is the presence of tight junctions which are present between cerebral endothelial cells and between choroid plexus epithelial cells. These junctions are present in blood vessels in fetal brain and are effective in restricting entry of proteins from blood into brain and cerebrospinal fluid. However, some features of the junctions appear to mature during brain development. 3. Although proteins do not penetrate into the extracellular space of the immature brain, they do penetrate into cerebrospinal fluid by a mechanism that is considered in the accompanying review (Dziegielewska et al., 2000). 4. In the immature brain there are additional morphological barriers at the interface between cerebrospinal fluid and brain tissue: strap junctions at the inner neuroependymal surface and these and other intercellular membrane specializations at the outer (piaarachnoid) surface. These barriers disappear later in development and are absent in the adult. 5. There is a decline in permeability to low molecular weight lipid-insoluble compounds during brain development which appears to be due mainly to a decrease in the intrinsic permeability of the blood-brain and blood-cerebrospinal fluid interfaces.
Keywords
Animals Astrocytes/cytology/physiology Blood-Brain Barrier/*physiology Brain/*blood supply/cytology/embryology/*physiology Cell Membrane Permeability/physiology Cerebrospinal Fluid/physiology Endothelium, Vascular/cytology/physiology Mice Proteins/metabolism Rats Sheep Tight Junctions/physiology
Pubmed
Web of science
Create date
24/01/2008 14:26
Last modification date
20/08/2019 15:25
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