Differential analgesic sensitivity of two distinct neuropathic pain models

Details

Serval ID
serval:BIB_B62557A297FE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differential analgesic sensitivity of two distinct neuropathic pain models
Journal
Anesthesia and Analgesia
Author(s)
Decosterd  I., Allchorne  A., Woolf  C. J.
ISSN
0003-2999 (Print)
Publication state
Published
Issued date
08/2004
Volume
99
Number
2
Pages
457-63, table of contents
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
Progressive tactile hypersensitivity (PTH) manifesting after sciatic nerve crush and spared nerve injury (SNI) are two distinct rodent experimental models of neuropathic pain. PTH develops months after recovery from the nerve crush in response to repeated intermittent low-threshold mechanical stimulation of the reinnervated sciatic nerve skin territory and represents a model of stimulus-induced pain. SNI is characterized by an early and sustained increase in stimulus-evoked pain sensitivity in the intact skin territory of the spared sural nerve after sectioning of the two other terminal branches of the sciatic nerve. We examined the effects of morphine (0.5-10 mg/kg), gabapentin (30-200 mg/kg), MK801 (0.01-0.02 mg/kg), amitriptyline (10-25 mg/kg), and carbamazepine (5-7.5 mg/kg) in both models. Morphine, gabapentin, and carbamazepine both reversed and prevented stimulus-induced PTH, whereas MK801 and amitriptyline reduced but did not prevent stimulus-induced PTH. In contrast, the stimulus-evoked behavioral hypersensitivity in the SNI model was poorly modified by these drugs. Independent neuropathic pain models show differential sensitivity to analgesic drug treatment. We suggest that this is due to the different mechanisms responsible for the neuropathic pain-related behavior. Multiple models are required, therefore, to study the mechanisms that contribute to neuropathic pain and to predict analgesic efficacy for different components of the neuropathic pain syndrome.
Keywords
Acetic Acids/therapeutic use *Amines Analgesics/*therapeutic use Analgesics, Opioid/therapeutic use Animals Cold *Cyclohexanecarboxylic Acids Disease Models, Animal Dizocilpine Maleate/therapeutic use Heat Hyperalgesia/prevention & control Male Morphine/therapeutic use Nerve Crush Neuroprotective Agents/therapeutic use Pain/*drug therapy/*etiology Pain Measurement/drug effects Peripheral Nervous System Diseases/*complications Physical Stimulation Rats Rats, Sprague-Dawley Sciatic Neuropathy/complications *gamma-Aminobutyric Acid
Pubmed
Web of science
Create date
28/01/2008 10:45
Last modification date
20/08/2019 15:24
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