Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin

Détails

ID Serval
serval:BIB_B5B7B624FD69
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin
Périodique
Human Pathology
Auteur(s)
Kempf  W., Haeffner  A. C., Zepter  K., Sander  C. A., Flaig  M. J., Mueller  B., Panizzon  R. G., Hardmeier  T., Adams  V., Burg  G.
ISSN
0046-8177 (Print)
Statut éditorial
Publié
Date de publication
10/2002
Volume
33
Numéro
10
Pages
1023-9
Notes
Journal Article --- Old month value: Oct
Résumé
Angiolymphoid hyperplasia with eosinophilia (ALHE) is commonly regarded an angioproliferative process characterized by the presence of prominent, bizarrely shaped blood vessels. These vessels are accompanied by an inflammatory infiltrate that is thought to be a reactive component. Both the cell of origin and the pathogenesis of ALHE remain controversial. To define the histogenesis of this disorder, we analyzed the phenotypic and genotypic profile of the inflammatory infiltrate in ALHE by immunohistochemistry and T-cell receptor gene rearrangement by polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis, as well as automated high-resolution PCR fragment analysis. Five of 7 ALHE patients displayed a clonal T-cell population and proliferative T-cell activity in lesional tissue. Most of these cases followed a protracted and therapy-reluctant course with recurrences. These data suggest that ALHE or a subset of ALHE cases harboring a clonal T-cell population may represent a T-cell lymphoproliferative disorder of a benign or low-grade malignant nature.
Mots-clé
Adult Aged Angiolymphoid Hyperplasia with Eosinophilia/etiology/*pathology/virology Cell Differentiation Cell Division Female Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Herpesvirus 8, Human/genetics Humans Male Middle Aged Polymerase Chain Reaction Receptors, Antigen, T-Cell, gamma-delta/genetics T-Lymphocyte Subsets/*pathology
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 15:24
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