Aldosterone-induced increase in the abundance of Na+ channel subunits

Détails

ID Serval
serval:BIB_B3C4046695C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Aldosterone-induced increase in the abundance of Na+ channel subunits
Périodique
American Journal of Physiology
Auteur(s)
Asher  C., Wald  H., Rossier  B. C., Garty  H.
ISSN
0363-6143
Statut éditorial
Publié
Date de publication
08/1996
Volume
271
Numéro
2 Pt 1
Pages
C605-11
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Aug
Résumé
The highly selective, amilorideblockable Na+ channel is a major target to the natriferic action of the mineralocorticoid aldosterone. This rat epithelial Na+ channel (rENaC) has been recently cloned from colon and is composed of three homologous subunits denoted alpha-, beta-, and gamma-rENaC (C. M. Canessa, L. Schild, G. Buell, B. Thorens, L. Gautschi, J.-D. Horisberger, and B. C. Rossier. Nature Lond. 367: 463-467, 1994). We have tested the effects of corticosteroids on the abundance of mRNA coding for each subunit in kidney cortex and distal colon. Chronic treatment of rats with aldosterone or dexamethasone evoked in kidney cortex a small induction of alpha-rENaC and no change in beta- and gamma-rENaC. In distal colon, however, beta- and gamma-rENaC were strongly induced by either aldosterone or dexamethasone, whereas alpha-rENaC was constitutively expressed. Most of the aldosterone-induced increase in beta- and gamma-rENaC mRNA took place during 3-24 h after plasma aldosterone was elevated. A similar differential induction of rENaC subunits in kidney and colon was also evoked by a Na(+)-free diet. The effects of salt deprivation were reversed by resalinating rats with a half time of < 2 h, suggesting a high turnover rate of at least beta- and gamma-rENaC. The data are consistent with the possibility that induction of channel subunits contributes to the chronic but not the acute response to aldosterone in the colon. Such a mechanism is not likely to play a major role in cortical collecting ducts.
Mots-clé
Aldosterone/*pharmacology Animals Colon/metabolism Dexamethasone/pharmacology Diet Female Kidney Cortex/metabolism Male Oocytes/metabolism RNA, Messenger/metabolism Rats Rats, Wistar Sodium Channels/genetics/*metabolism Sodium Chloride/administration & dosage/pharmacology Time Factors Xenopus
Pubmed
Web of science
Création de la notice
24/01/2008 13:00
Dernière modification de la notice
20/08/2019 15:22
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