Vaccines: an ongoing promise?

Details

Serval ID
serval:BIB_B3A0E54C1DD7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Vaccines: an ongoing promise?
Journal
Digestive Diseases
Author(s)
Alsahli  M., Farrell  R. J., Michetti  P.
ISSN
0257-2753 (Print)
Publication state
Published
Issued date
2001
Volume
19
Number
2
Pages
148-57
Notes
Journal Article
Review
Abstract
Over the past decade, intensive research has focused on developing a vaccine therapy for Helicobacter pylori. Substantial unresolved questions cloud the current approach, and the development of a vaccine against this unique organism has proved very challenging. Many candidate vaccines have been tested in animal models. The immunogenicity and the safety of some vaccine formulations have been recently evaluated through clinical trials, and the efficacy of these vaccine therapies in humans will be determined in the near future. This article will provide an overview of the current knowledge of natural and vaccine-induced immune responses to H. pylori infection. It will also review past vaccine successes and failures in animal models and the limited experience to date in using vaccine therapy in humans. Several obstacles to H. pylori vaccine development efforts along with the future direction of these efforts will be discussed.
Keywords
Animals Antigens, Bacterial/immunology Bacterial Vaccines/*immunology Clinical Trials Disease Models, Animal Helicobacter Infections/*immunology/*prevention & control Helicobacter pylori/*immunology/pathogenicity Humans Immunity, Cellular Immunization
Pubmed
Web of science
Create date
25/01/2008 16:02
Last modification date
20/08/2019 15:22
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