Differential phosphorylation of tau proteins during kitten brain development and Alzheimer's disease.

Détails

ID Serval
serval:BIB_B37910CA7847
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential phosphorylation of tau proteins during kitten brain development and Alzheimer's disease.
Périodique
Journal of Neurocytology
Auteur(s)
Riederer B.M., Mourton-Gilles C., Frey P., Delacourte A., Probst A.
ISSN
0300-4864 (Print)
ISSN-L
0300-4864
Statut éditorial
Publié
Date de publication
2001
Volume
30
Numéro
2
Pages
145-158
Langue
anglais
Résumé
Differential distribution and phosphorylation of tau proteins were studied in developing kitten brain by using several antibodies, and was compared to phosphorylation in Alzheimer's disease. Several antibodies demonstrated the presence of phosphorylated tau proteins during kitten brain development and identified pathological structures in human brain tissue. Antibody AD2, recognized tau in kittens and adult cats, but reacted in Alzheimer's tissue only with a pathological tau form. Antibody AT8 was prominent in developing kitten neurons and was found in axons and dendrites. After the first postnatal month this phosphorylation type disappeared from axons. Furthermore, dephosphorylation of kitten tau with alkaline phosphatase abolished immunoreactivity of AT8, but not that of AD2, pointing to a protection of the AD2 epitope in cats. Tau proteins during early cat brain development are phosphorylated at several sites that are also phosphorylated in paired helical filaments during Alzheimer's disease. In either event, phosphorylation of tau may play a crucial role to modulate microtubule dynamics, contributing to increased microtubule instability and promoting growth of processes during neuronal development or changing dynamic properties of the cytoskeleton and contributing to the formation of pathological structures in neurodegenerative diseases.
Mots-clé
Aged, Aged, 80 and over, Aging/metabolism, Alzheimer Disease/metabolism, Animals, Animals, Newborn, Brain/growth & development, Brain/metabolism, Cats, Electrophoresis, Polyacrylamide Gel, Female, Humans, Immunoblotting, Immunohistochemistry, Male, Phosphorylation, tau Proteins/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:34
Dernière modification de la notice
03/03/2018 20:40
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