Radiation Therapy after Radical Prostatectomy: Implications for Clinicians.

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Ressource 1Télécharger: BIB_B2C625B19773.P001.pdf (175.18 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_B2C625B19773
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Radiation Therapy after Radical Prostatectomy: Implications for Clinicians.
Périodique
Frontiers In Oncology
Auteur(s)
Herrera F.G., Berthold D.R.
ISSN
2234-943X (Electronic)
ISSN-L
2234-943X
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
6
Pages
117
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: epublish
Résumé
Depending on the pathological findings, up to 60% of prostate cancer patients who undergo radical prostatectomy (RP) will develop biochemical relapse and require further local treatment. Radiotherapy (RT) immediately after RP may potentially eradicate any residual localized microscopic disease in the prostate bed, and it is associated with improved biochemical, clinical progression-free survival, and overall survival in patients with high-risk pathological features according to published randomized trials. Offering immediate adjuvant RT to all men with high-risk pathological factors we are over-treating around 50% of patients who would anyway be cancer-free, exposing them to unnecessary toxicity and adding costs to the health-care system. The current dilemma is, thus, whether to deliver adjuvant immediate RT solely on the basis of high-risk pathology, but in the absence of measurable prostate-specific antigen, or whether early salvage radiotherapy would yield equivalent outcomes. Randomized trials are ongoing to definitely answer this question. Retrospective analyses suggest that there is a dose-response favoring doses >70 Gy to the prostate bed. The evidence regarding the role of androgen deprivation therapy is emerging, and ongoing randomized trials are underway.
Pubmed
Open Access
Oui
Création de la notice
14/06/2016 16:12
Dernière modification de la notice
20/08/2019 15:21
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