Endothelin B receptor, a new target in cancer immune therapy.

Details

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_B040F90D1DBC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Endothelin B receptor, a new target in cancer immune therapy.
Journal
Clinical Cancer Research
Author(s)
Kandalaft L.E., Facciabene A., Buckanovich R.J., Coukos G.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Publication state
Published
Issued date
2009
Volume
15
Number
14
Pages
4521-4528
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
The endothelins and their G protein-coupled receptors A and B have been implicated in numerous diseases and have recently emerged as pivotal players in a variety of malignancies. Tumors overexpress the endothelin 1 (ET-1) ligand and the endothelin-A-receptor (ET(A)R). Their interaction induces tumor growth and metastasis by promoting tumor cell survival and proliferation, angiogenesis, and tissue remodeling. On the basis of results from xenograft models, drug development efforts have focused on antagonizing the autocrine-paracrine effects mediated by ET-1/ET(A)R. In this review, we discuss a novel role of the endothelin-B-receptor (ET(B)R) in tumorigenesis and the effect of its blockade during cancer immune therapy. We highlight key characteristics of the B receptor such as its specific overexpression in the tumor compartment; and specifically, in the tumor endothelium, where its activation by ET-1 suppresses T-cell adhesion and homing to tumors. We also review our recent findings on the effects of ET(B)R-specific blockade in increasing T-cell homing to tumors and enhancing the efficacy of otherwise ineffective immunotherapy.
Keywords
Animals, Endothelium, Vascular/drug effects, Endothelium, Vascular/metabolism, Humans, Immunotherapy/methods, Intercellular Adhesion Molecule-1/metabolism, Models, Biological, Neoplasms/immunology, Neoplasms/metabolism, Oligopeptides/pharmacology, Piperidines/pharmacology, Receptor, Endothelin B/antagonists & inhibitors, Receptor, Endothelin B/metabolism, T-Lymphocytes/drug effects, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Yes
Create date
14/10/2014 11:42
Last modification date
20/08/2019 15:19
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