Lifespan differences between queens and workers are not explained by rates of molecular damage.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_B01FFA3CC6EE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Lifespan differences between queens and workers are not explained by rates of molecular damage.
Périodique
Experimental Gerontology
Auteur(s)
Lucas E.R., Augustyniak M., Kędziorski A., Keller L.
ISSN
1873-6815 (Electronic)
ISSN-L
0531-5565
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
92
Pages
1-6
Langue
anglais
Résumé
The biological processes that underlie senescence are of universal biological importance, yet they remain poorly understood. A popular theory proposes that senescence is the result of limited investment into mechanisms involved in the prevention and repair of molecular damage, leading to an accumulation of molecular damage with age. In ants, queen and worker lifespans differ by an order of magnitude, and this remarkable difference in lifespan has been shown to be associated with differences in the expression of genes involved in DNA and protein repair. Here we use the comet assay and Western Blotting for poly-ubiquitinated proteins to explore whether these differences in expression lead to differences in the accumulation of DNA damage (comet assay) or protein damage (protein ubiquitination) with age. Surprisingly, there was no difference between queens and workers in the rate of accumulation of DNA damage. We also found that levels of ubiquitinated proteins decreased with age, as previously reported in honeybees. This is in contrast to what has been found in model organisms such as worms and flies. Overall, these results reveal that the link between investment into macromolecular repair, age-related damage accumulation and lifespan is more complex than usually recognised.

Mots-clé
Ageing, Lifespan, Somatic maintenance, Social insects, DNA damage
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/03/2017 19:34
Dernière modification de la notice
08/05/2019 23:48
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