The use of the rapid D-dimer test for the exclusion of acute venous thromboembolism in a regional hospital.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_AD62D980B027
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The use of the rapid D-dimer test for the exclusion of acute venous thromboembolism in a regional hospital.
Journal
Swiss medical weekly
Author(s)
Fumeaux T., Cornuz J.
ISSN
1424-7860 (Print)
ISSN-L
0036-7672
Publication state
Published
Issued date
22/03/2003
Peer-reviewed
Oui
Volume
133
Number
11-12
Pages
178-183
Language
english
Notes
Publication types: Evaluation Studies ; Journal Article
Publication Status: ppublish
Abstract
The performance of rapid D-dimer ELISA assay has been validated as a part of various diagnostic work-ups in tertiary care hospitals for the exclusion of acute thromboembolism in the medical emergency department. In order to measure the performance of this test outside of predetermined protocols and in a different medical setting, we retrospectively analysed a cohort of adult patients admitted to the emergency department of a regional hospital with a suspicion of acute venous thromboembolism.
All D-dimer assays performed during an 18-month period were retrieved. The patients' data were collected from hospital charts. Six-month follow-up was determined either by a written or telephone questionnaire or after contact with the patient's physician. The patients for whom this process was completed were included in the study and a retrospective diagnostic assessment was performed using a combination of clinical probability and objective testing. The diagnosis was then compared to the result of the initial D-dimer assay.
During the study period 494 patients were included with 110 venous thromboembolic episodes. The sensitivity and negative predictive value of the D-dimer assay were respectively 94.5% (95% CI 88.4 to 97.7%) and 96.8% (95% CI 93.2 to 98.7%).
The yield of the rapid D-dimer assay in this study is comparable to the results of management studies performed in tertiary centres. D-dimer ELISA assay can be used to exclude venous thromboembolism, particularly in cases with a low clinical probability, in the emergency department and for larger populations in various clinical settings, even in the absence of a formal diagnostic work-up. False negative results can occur, particularly in the presence of a high clinical probability of acute thromboembolism.

Keywords
Acute Disease, Adult, Aged, Antifibrinolytic Agents/blood, Cohort Studies, Emergency Service, Hospital, Enzyme-Linked Immunosorbent Assay, Female, Fibrin Fibrinogen Degradation Products/analysis, Humans, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Sensitivity and Specificity, Thromboembolism/blood, Thromboembolism/diagnosis, Time Factors, Venous Thrombosis/blood, Venous Thrombosis/diagnosis
Pubmed
Web of science
Create date
25/01/2008 13:42
Last modification date
20/08/2019 15:17
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