Free circulating magnesium and renal magnesium handling during acute metabolic acidosis in humans

Details

Serval ID
serval:BIB_ACF3DF4C581A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Free circulating magnesium and renal magnesium handling during acute metabolic acidosis in humans
Journal
American Journal of Nephrology
Author(s)
Blumberg  D., Bonetti  A., Jacomella  V., Capillo  S., Truttmann  A. C., Luthy  C. M., Colombo  J. P., Bianchetti  M. G.
ISSN
0250-8095 (Print)
Publication state
Published
Issued date
1998
Volume
18
Number
3
Pages
233-6
Notes
Journal Article
Abstract
Ion-selective electrodes have been designed for determining the ionized concentration of magnesium in blood, the biologically active form of this ion. The effect of acute acidosis induced by ammonium loading on circulating and urinary magnesium was investigated in 11 volunteers. No changes in plasma total and ionized magnesium were noted following administration of ammonium chloride. On the contrary, administration of ammonium chloride increased the plasma free magnesium fraction and the urinary magnesium excretion. The study demonstrates that the hypermagnesiuria induced by acute acidosis is not caused by ionized hypermagnesemia and supports the theory that acidosis decreases the circulating magnesium fraction that is bound to proteins.
Keywords
Acidosis/chemically induced/*metabolism/urine Acute Disease Adult Ammonium Chloride Humans Ion-Selective Electrodes Kidney/*metabolism Magnesium/*metabolism Male
Pubmed
Web of science
Create date
28/01/2008 13:50
Last modification date
20/08/2019 15:16
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