Etude comparative de la tolérance oculaire de 3 spécialités à base de timolol: influence du conservateur sur la tolérance oculaire [A comparative study of the ocular tolerance of 3 timolol-based preparations: the influence of preservatives on ocular tolerance]
Details
Serval ID
serval:BIB_ACA8A36D56BA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Etude comparative de la tolérance oculaire de 3 spécialités à base de timolol: influence du conservateur sur la tolérance oculaire [A comparative study of the ocular tolerance of 3 timolol-based preparations: the influence of preservatives on ocular tolerance]
Journal
Journal francais d'ophtalmologie
ISSN
0181-5512 (Print)
ISSN-L
0181-5512
Publication state
Published
Issued date
01/2001
Peer-reviewed
Oui
Volume
24
Number
1
Pages
13-19
Language
french
Notes
Publication types: Comparative Study ; English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Ophthalmic preparations can cause toxic ocular reactions, often associated with the use of preservatives. The aim of this study was to compare the ocular tolerance of three ophthalmic preparations based on timolol: a preservative free ophthalmic preparation (Timabak) and two other commercially available preserved preparations (Timoptol) and Timoptol LP).
The effect of repeatedly instilling eye drops for 28 days on rabbit eyes was assessed in vivo by mean of a confocal laser scanning ophthalmoscope. The corneal microlesions were selectively marked by fluorescein.
The overall results show the good ocular tolerance of the three tested products. However, a closer comparison between the products brought out differences in the extent of lesions among the tested products depending on their composition. Indeed the preservative free eye drops appeared better tolerated than the two preserved preparations.
The effect of repeatedly instilling eye drops for 28 days on rabbit eyes was assessed in vivo by mean of a confocal laser scanning ophthalmoscope. The corneal microlesions were selectively marked by fluorescein.
The overall results show the good ocular tolerance of the three tested products. However, a closer comparison between the products brought out differences in the extent of lesions among the tested products depending on their composition. Indeed the preservative free eye drops appeared better tolerated than the two preserved preparations.
Keywords
Adrenergic beta-Antagonists/administration & dosage, Adrenergic beta-Antagonists/toxicity, Animals, Ophthalmic Solutions, Rabbits, Timolol/administration & dosage, Timolol/toxicity
Pubmed
Web of science
Create date
06/01/2019 14:37
Last modification date
20/08/2019 16:16
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