Perfusion-weighted magnetic resonance imaging patterns of hypoxic-ischemic encephalopathy in term neonates.

Details

Serval ID
serval:BIB_AC5B7C005A58
Type
Article: article from journal or magazin.
Collection
Publications
Title
Perfusion-weighted magnetic resonance imaging patterns of hypoxic-ischemic encephalopathy in term neonates.
Journal
Journal of Magnetic Resonance Imaging
Author(s)
Wintermark P., Moessinger A.C., Gudinchet F., Meuli R.
ISSN
1053-1807
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
28
Number
4
Pages
1019-1025
Language
english
Notes
Publication types: Journal Article
Abstract
PURPOSE: To determine whether an early magnetic resonance imaging (MRI) study using perfusion-weighted imaging (PWI) may define the pattern of brain injury in term neonatal hypoxic-ischemic (HI) encephalopathy. MATERIALS AND METHODS: Five newborns with HI encephalopathy or a marker of perinatal depression, and 2 controls underwent an early MRI (at 2 to 4 days), including PWI. Relative cerebral blood flow (rCBF) values were measured. RESULTS: On early (<or=4 days) PWI-MRI, marked hyperperfusion was seen in areas of HI brain damage, allowing the classification of the children into different patterns according to the predominant site of injury: 1 with a "normal pattern"; 1 with a "watershed pattern" with increased rCBF ratios in white matter; 1 with a "basal ganglia pattern" with increased rCBF ratios in basal ganglia; and 2 with a "total cortical pattern" with increased rCBF ratios in cortical gray matter, white matter, and basal ganglia. These patterns were confirmed in all infants on late (9 to 11 days) conventional MRI (T2-weighted images) (4 of 5 patients) or on postmortem examination (1 of 5 patients). CONCLUSION: PWI is technically feasible in neonates with HI encephalopathy in a reproducible way, permitting comparisons between children. It provides a practical means to identify early after birth the future definitive ischemic areas that may be shown on conventional MRI only later.
Keywords
Case-Control Studies, Cerebrovascular Circulation, Contrast Media, Female, Gadolinium DTPA/diagnostic use, Humans, Hypoxia-Ischemia, Brain/diagnosis, Hypoxia-Ischemia, Brain/pathology, Infant, Newborn, Magnetic Resonance Angiography/methods, Male, Prospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2009 18:05
Last modification date
20/08/2019 15:16
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