Predator or prey? Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU.

Details

Serval ID
serval:BIB_AC1F744F0EA5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predator or prey? Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU.
Journal
Microbes and Infection / Institut Pasteur
Author(s)
Wirz M., Polkinghorne A., Dumrese C., Ziegler U., Greub G., Pospischil A., Vaughan L.
ISSN
1286-4579 (Print)
ISSN-L
1286-4579
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
10
Number
6
Pages
591-597
Language
english
Abstract
Limited evidence exists to suggest that the ability to invade and escape protozoan host cell bactericidal activity extends to members of the Chlamydiaceae, intracellular pathogens of humans and animals and evolutionary descendants of amoeba-resisting Chlamydia-like organisms. PCR and microscopic analyses of Chlamydophila abortus infections of Acanthamoeba castellani revealed uptake of this chlamydial pathogen but, unlike the well-described inhabitant of A. castellani, Parachlamydia acanthamoebae, Cp. abortus did not appear to propagate and is likely digested by its amoebal host. These data raise doubts about the ability of free-living amoebae to serve as hosts and vectors of pathogenic members of the Chlamydiaceae but reveal opportunities, via comparative genomics, to understand virulence mechanisms used by Chlamydia-like organisms to avoid amoebal digestion.
Keywords
Acanthamoeba castellanii/microbiology, Acanthamoeba castellanii/physiology, Animals, Chlamydophila/physiology, Chlamydophila Infections/microbiology, Host-Parasite Interactions/physiology, Virulence/physiology
Pubmed
Web of science
Create date
03/04/2016 21:07
Last modification date
20/08/2019 15:16
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