Is there histomorphological evidence of plantar metatarsal fat pad atrophy in patients with diabetes?

Détails

ID Serval
serval:BIB_ABA7A5542DB5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Is there histomorphological evidence of plantar metatarsal fat pad atrophy in patients with diabetes?
Périodique
Journal of Foot and Ankle Surgery
Auteur(s)
Waldecker U., Lehr H.A.
ISSN
1542-2224[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
48
Numéro
6
Pages
648-652
Langue
anglais
Résumé
The etiology of diabetic foot ulceration remains incompletely understood. Among other factors such as foot deformity in the presence of neuropathy, plantar fat pad atrophy has been identified as a contributory factor in diabetic foot ulceration. An association between fat pad atrophy and diabetic foot ulceration has been documented by imaging and histomorphological analysis of the calcaneal fat pad. However, histomorphological analysis of the metatarsal fat pad has not been performed to date. The present study entailed 14 patients with diabetes and 14 nondiabetic controls and was aimed at documenting histomorphological evidence for presumed plantar metatarsal fat pad atrophy in patients with diabetes. Histological stains and computer-assisted planimetry were performed on samples of metatarsal fat obtained during forefoot surgery. The histomorphological and planimetric analyses of adipocyte cross-sectional area and nuclear density demonstrated no differences between patients with diabetes and control patients. Our findings demonstrate that systemic atrophy of the metatarsal fat pad is not present in the diabetic foot and may not explain the structural changes previously proposed by noninvasive imaging. Level of Clinical Evidence: 3.
Mots-clé
Diabetes Mellitus, Foot, Histomorphological, Neuropathy, Ulcer , Toe Deformity, Foot, Tissue, Pressures, Histology
Pubmed
Web of science
Création de la notice
10/11/2009 14:59
Dernière modification de la notice
03/03/2018 20:26
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