Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography.

Details

Serval ID
serval:BIB_ABA430E6B208
Type
Article: article from journal or magazin.
Collection
Publications
Title
Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography.
Journal
Journal of Neurology, Neurosurgery, and Psychiatry
Author(s)
Derbyshire S.W., Jones A.K., Devani P., Friston K.J., Feinmann C., Harris M., Pearce S., Watson J.D., Frackowiak R.S.
ISSN
0022-3050 (Print)
ISSN-L
0022-3050
Publication state
Published
Issued date
1994
Volume
57
Number
10
Pages
1166-1172
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The localised PET cerebral correlates of the painful experience in the normal human brain have previously been demonstrated. This study examined whether these responses are different in patients with chronic atypical facial pain. The regional cerebral responses to non-painful and painful thermal stimuli in six female patients with atypical facial pain and six matched female controls were studied by taking serial measurements of regional blood flow by PET. Both groups displayed highly significant differences in responses to painful heat compared with non-painful heat in the thalamus, anterior cingulate cortex (area 24), lentiform nucleus, insula, and prefrontal cortex. These structures are closely related to the "medial pain system". The atypical facial pain group had increased blood flow in the anterior cingulate cortex and decreased blood flow in the prefrontal cortex. These findings show the importance of the anterior cingulate cortex and the reciprocal (possibly inhibitory) connections with the prefrontal cortex in the processing of pain in patients with this disorder. A hypothesis is proposed to explain the mechanisms of cognitive and pharmacological manipulation of these pain processes.
Keywords
Adult, Aged, Brain/physiopathology, Brain/radionuclide imaging, Case-Control Studies, Facial Pain/physiopathology, Facial Pain/radionuclide imaging, Female, Humans, Middle Aged, Tomography, Emission-Computed
Pubmed
Web of science
Open Access
Yes
Create date
16/09/2011 20:38
Last modification date
20/08/2019 15:15
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