Les bisphosphonates dans l'hypercalcémie maligne et les douleurs osseuses. [Bisphosphonates in malignant hypercalcemia and bone pain]

Details

Serval ID
serval:BIB_AB7FB059ACA0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Les bisphosphonates dans l'hypercalcémie maligne et les douleurs osseuses. [Bisphosphonates in malignant hypercalcemia and bone pain]
Journal
Revue Médicale de la Suisse Romande
Author(s)
Lamy  O.
ISSN
0035-3655 (Print)
Publication state
Published
Issued date
02/2004
Volume
124
Number
2
Pages
111-4
Notes
English Abstract Journal Article Review --- Old month value: Feb
Abstract
The skeleton is the most common organ to be affected by metastatic cancer. Hypercalcemia of malignancy (HM) affects 10 to 20% of patients with advanced cancer. HM causes a series of symptoms, constipation, nausea and vomiting, confusion and/or stupor, polyuria and polydipsia, bone pains, which decrease quality of life. The normalization of calcemia significantly improves all these symptoms. Despite that, HM remains largely underdiagnosed and undertreated. HM is an emergency. Treatment of HM includes rapid rehydration of isotonic saline and i.v. bisphosphonates. Complications from metastatic bone disease include pathological fracture, HM, spinal cord compression, bone marrow infiltration, pain, and reduced mobility. Treatment with bisphosphonates are effective to reduce these complications. They should be started when bone metastases are diagnosed and continue until it is no longer clinically relevant. The most currently used bisphosphonates were clodronate and pamidronate. The increase convenience of a 15 minutes infusion, the greater efficacy and longer duration of response makes zoledronate the standard of care for HM and metastatic bone disease.
Keywords
Bone Neoplasms/*complications/secondary Diagnosis, Differential Diphosphonates/*therapeutic use Humans Hypercalcemia/diagnosis/*drug therapy/epidemiology/etiology Incidence Pain/*etiology/therapy Prevalence
Pubmed
Create date
25/01/2008 13:55
Last modification date
20/08/2019 15:15
Usage data