Immunohistochemical Biomarkers of Gastrointestinal, Pancreatic, Pulmonary, and Thymic Neuroendocrine Neoplasms.

Détails

ID Serval
serval:BIB_AB309A2F401C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Immunohistochemical Biomarkers of Gastrointestinal, Pancreatic, Pulmonary, and Thymic Neuroendocrine Neoplasms.
Périodique
Endocrine pathology
Auteur(s)
Uccella S., La Rosa S., Volante M., Papotti M.
ISSN
1559-0097 (Electronic)
ISSN-L
1046-3976
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
29
Numéro
2
Pages
150-168
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Neuroendocrine neoplasms (NENs) are a heterogeneous group of epithelial neoplastic proliferations that irrespective of their primary site share features of neural and endocrine differentiation including the presence of secretory granules, synaptic-like vesicles, and the ability to produce amine and/or peptide hormones. NENs encompass a wide spectrum of neoplasms ranging from well-differentiated indolent tumors to highly aggressive poorly differentiated neuroendocrine carcinomas. Most cases arise in the digestive system and in thoracic organs, i.e., the lung and thymus. A correct diagnostic approach is crucial for the management of patients with both digestive and thoracic NENs, because their high clinical and biological heterogeneity is related to their prognosis and response to therapy. In this context, immunohistochemistry represents an indispensable diagnostic tool that pathologists need to use for the correct diagnosis and classification of such neoplasms. In addition, immunohistochemistry is also useful in identifying prognostic and theranostic markers. In the present article, the authors will review the role of immunohistochemistry in the routine workup of digestive and thoracic NENs.
Mots-clé
Biomarkers, Tumor/analysis, Gastrointestinal Neoplasms/diagnosis, Humans, Immunohistochemistry/methods, Lung Neoplasms/diagnosis, Neuroendocrine Tumors/diagnosis, Pancreatic Neoplasms/diagnosis, Pathology, Clinical/methods, Thymus Neoplasms/diagnosis, Diagnosis, prognosis, Immunohistochemistry, Neuroendocrine carcinoma, Neuroendocrine tumor
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/03/2018 9:37
Dernière modification de la notice
20/08/2019 15:15
Données d'usage