According to a study published by the European Commission in 2011 and including 290 millions men from 34 different countries, among which Switzerland, the male population has a much higher mortality and morbidity rate than its female counterpart. When a man reaches his fortierth year, he ​is at the top of his abilities in many areas : he benefits from a strong life experience and the deficits related to aging do not impact his wellbeing yet. What about his health ? Most of the recommendations in terms of screening begin at age 50. So forties can appear as a grey area. This article reviews the screening indicated for a patient around forty years old. It intends to offer a complement to publications regarding screening and prevention that are regularly published in this journal.