Effect of lipopolysaccharide and superantigens on T-cell activation by lung macrophages and dendritic cells

Details

Serval ID
serval:BIB_A74939A24A7E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effect of lipopolysaccharide and superantigens on T-cell activation by lung macrophages and dendritic cells
Journal
European Respiratory Review
Author(s)
Isler P., Nicod L.P.
ISSN
0905-9180
Publication state
Published
Issued date
2000
Volume
10
Number
70
Pages
133-138
Language
english
Abstract
Until recently, innate and acquired immunity were perceived to be rather independent of each other. It was obvious by 1992 that alveolar macrophages and natural killer (NK) cells, by releasing tumour necrosis factor-α and interferon-γ (IFN-γ), respectively, play a central role in the innate response, whereas T-helper (h)1 and Th2 T-cells downregulate each other by their respective cytokines, IFN-γ and interleukin-4 (IL-4), during acquired immunity. It is now becoming clear that the divergence into Th1 and Th2 cells is regulated by the innate immune response, mainly through the release of IL-12 by macrophages and the release of IL-4 by CD4+ NK1.1 cells. As dendritic cells initiate specific T-cell acquired immunity, understanding the influence of cytokines produced by the innate immune system on dendritic cell maturation and function will be an important goal of future research. As macrophages are the main source of cytokine production in the lung during bacterial infection, the important role of bacterial lipopolysaccharides and superantigens in both innate and acquired immunity will be discussed.
Keywords
cell function, cell maturation, cellular immunity, cytokine release, dendritic cell, immune response, immunity, lung alveolus macrophage, macrophage, natural killer cell, review, T lymphocyte activation, Th1 cell, Th2 cell
Create date
23/02/2010 15:23
Last modification date
20/08/2019 15:12
Usage data