Gynecomastia with unusual intraductal "clear cell" changes mimicking pagetoid ductal spread of lobular neoplasia
Details
Serval ID
serval:BIB_A6BB854CE3CA
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Gynecomastia with unusual intraductal "clear cell" changes mimicking pagetoid ductal spread of lobular neoplasia
Journal
Pathology Research and Practice
ISSN
0344-0338 (Print)
Publication state
Published
Issued date
1995
Volume
191
Number
2
Pages
156-163
Notes
PT - Case Reports PT - Journal Article
Abstract
This report describes a case of unusual intraductal "clear cell" changes of male breast that mimicked pagetoid ductal spread of lobular neoplasia. The lesion developed inside a nodule of gynecomastia of the left breast in a 56 year-old man. Immunohistochemically, the enlarged clear cells reacted positively with epithelial membrane antigen, low molecular weight cytokeratin and three breast markers (i.e.: gross cystic disease fluid protein-15 and -44 and estrogen receptors). They were negative for high molecular weight cytokeratin, muscle-specific actin, desmin and vimentin. Differential diagnoses included pagetoid ductal involvement by lobular neoplasia (i.e.: lobular carcinoma in situ and/or atypical lobular hyperplasia), pagetoid growth of intraductal carcinoma, atypical intraductal hyperplasia, and unusual intraductal myoepithelial proliferative lesion
Keywords
Diagnosis,Differential/Gynecomastia/diagnosis/Pathology/Humans/Hyperplasia/Male/Middle Aged/Paget's Disease,Mammary
Pubmed
Web of science
Create date
29/01/2008 19:36
Last modification date
20/08/2019 16:11