Primary progressive multifocal leukoencephalopathy presenting as an extrapyramidal syndrome.

Details

Serval ID
serval:BIB_A6522C286CE6
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Primary progressive multifocal leukoencephalopathy presenting as an extrapyramidal syndrome.
Journal
Journal of Neurology
Author(s)
Bhatia K.P., Morris J.H., Frackowiak R.S.
ISSN
0340-5354 (Print)
ISSN-L
0340-5354
Publication state
Published
Issued date
1996
Volume
243
Number
1
Pages
91-95
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
We report a 63-year-old woman with a progressive illness which began as a parkinsonian syndrome with bilateral rest tremor, limb rigidity and a gait disorder followed by cognitive decline, visuomotor apraxia and visual agnosia. She died 10 years after the onset of the illness and at autopsy the brain showed characteristic changes of progressive multifocal leukoencephalopathy (PML) with the presence of the JC virus confirmed by in situ hybridisation. Neuropathology also showed some unusual features in the form of atypical linear lesions at the cortico-white matter junction. Some of these lesions were active while others were inactive and similar to the rarely described "burnt out" lesions of PML. PML can in rare cases occur without an underlying immune disorder or malignancy (primary PML) and a parkinsonian syndrome can be produced by a predominantly white matter disorder.
Keywords
Basal Ganglia Diseases/diagnosis, Diagnosis, Differential, Female, Humans, JC Virus/isolation & purification, Leukoencephalopathy, Progressive Multifocal/diagnosis, Leukoencephalopathy, Progressive Multifocal/pathology, Middle Aged, Syndrome
Pubmed
Web of science
Create date
16/09/2011 19:21
Last modification date
20/08/2019 15:11
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