Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry.

Details

Serval ID
serval:BIB_A58CCF8B8AD1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine in human hair by gas chromatography-mass spectrometry.
Journal
Journal of Chromatography. B, Biomedical Applications
Author(s)
Kintz P., Cirimele V., Tracqui A., Mangin P.
ISSN
1572-6495[print], 1572-6495[linking]
Publication state
Published
Issued date
1995
Volume
670
Number
1
Pages
162-166
Language
english
Abstract
A procedure is presented for the simultaneous identification and quantification of amphetamine (AP), methamphetamine (MA), methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) in human hair. The method involves decontamination of hair with dichloromethane and warm water, heat-alkaline hydrolysis in the presence of deuterated internal standards, liquid-liquid extraction and gas chromatography-mass spectrometry after derivatization with pentafluoropropionic anhydride-pentafluoropropanol. The limit of detection for AP, MA and MDA was 0.05 ng/mg using a 50-mg hair sample; for MDMA it was 0.1 ng/mg. Coefficients of variation ranged from 7 to 18%. This assay has been successfully utilized in the evaluation of the deposition of the drugs in hair obtained from various parts of the anatomy of a stimulant abuser.
Keywords
3,4-Methylenedioxyamphetamine/analysis, Amphetamine/analysis, Gas Chromatography-Mass Spectrometry/methods, Hair/chemistry, Humans, Methamphetamine/analysis, N-Methyl-3,4-methylenedioxyamphetamine/analysis, Reproducibility of Results, Substance-Related Disorders/diagnosis
Pubmed
Create date
19/10/2010 15:30
Last modification date
20/08/2019 15:10
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