Thermal radiofrequency induced porcine ureteral stricture: a convenient endourologic model.

Détails

ID Serval
serval:BIB_A55C0F68E20D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Thermal radiofrequency induced porcine ureteral stricture: a convenient endourologic model.
Périodique
Journal of Urology
Auteur(s)
Anidjar M., Mongiat-Artus P., Brouland J.P., Meria P., Teillac P., Le Duc A., Berthon P., Cussenot O.
ISSN
0022-5347 (Print)
ISSN-L
0022-5347
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
161
Numéro
1
Pages
298-303
Langue
anglais
Résumé
PURPOSE: To establish a reliable model of iatrogenic ureteral stricture mimicking the human clinical situation in order to experiment with new site-specific endourologic treatment concepts.
MATERIALS AND METHODS: After cystoscopic insertion of a 7F right ureteral catheter, we induced external thermal radiofrequency injury to the right upper third ureter at low power setting (10 W) using an open surgical approach in 13 pigs. Three pigs considered as controls underwent the same procedure without application of electrocautery. All 16 animals were initially assessed at 8 days; 3 study animals and the 3 controls were followed for 6 weeks.
RESULTS: No control animals had strictures. Significant upper third ureteral strictures with marked hydronephrosis where achieved in all study animals after a mean interval of 9 days, as evidenced by ultrasound examination and retrograde ureteropyelography. Endoscopic retrograde access to these strictures was always possible (mean length 1.4 cm.). Histologic examination displayed severe disorganization of the muscular layer by dense fibrosis composed of collagen bundles with few scattered fibroblasts. No spontaneous improvement of the stricture was observed in the 3 animals reassessed at 6 weeks.
CONCLUSIONS: Externally applied radiofrequency energy to porcine ureter provides a reproducible model of fibrous stricture resembling its clinical counterparts.
Mots-clé
Animals, Disease Models, Animal, Electrocoagulation, Female, Swine, Ureteral Obstruction/etiology, Ureteral Obstruction/pathology
Pubmed
Web of science
Création de la notice
13/10/2015 10:14
Dernière modification de la notice
03/03/2018 20:15
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