Chlamydiales and the innate immune response: friend or foe?

Détails

ID Serval
serval:BIB_A4C733268C13
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Chlamydiales and the innate immune response: friend or foe?
Périodique
Fems Immunology and Medical Microbiology
Auteur(s)
Rusconi B., Greub G.
ISSN
1574-695X (Electronic)
ISSN-L
0928-8244
Statut éditorial
Publié
Date de publication
2011
Volume
61
Numéro
3
Pages
231-244
Langue
anglais
Résumé
Pathogenicity of Chlamydia and Chlamydia-related bacteria could be partially mediated by an enhanced activation of the innate immune response. The study of this host pathogen interaction has proved challenging due to the restricted in vitro growth of these strict intracellular bacteria and the lack of genetic tools to manipulate their genomes. Despite these difficulties, the interactions of Chlamydiales with the innate immune cells and their effectors have been studied thoroughly. This review aims to point out the role of pattern recognition receptors and signal molecules (cytokines, reactive oxygen species) of the innate immune response in the pathogenesis of chlamydial infection. Besides inducing clearance of the bacteria, some of these effectors may be used by the Chlamydia to establish chronic infections or to spread. Thus, the induced innate immune response seems to be variable depending on the species and/or the serovar, making the pattern more complex. It remains crucial to determine the common players of the innate immune response in order to help define new treatment strategies and to develop effective vaccines. The excellent growth in phagocytic cells of some Chlamydia-related organisms such as Waddlia chondrophila supports their use as model organisms to study conserved features important for interactions between the innate immunity and Chlamydia.
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/04/2011 9:51
Dernière modification de la notice
08/05/2019 23:10
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